Characters : S
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Salesman
- Moustachioed, sarcastic salesman who has been employed at various shops including Bloodbath and Beyond Gun Shop, the gadget shop, the pet shop, "Sporticus" and the Aphrodite Inn. Even manages to be sarcastic to the Comic Book Guy.
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Salvadore
- Chef at Luigi's restaurant.
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Sam
- Drinks at Moe's Tavern with Homer, Carl and Lenny. Wears cap and glasses.
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Santa's Little Helper
- Bart's dog. Was rescued by Homer from a greyhound circuit at Christmas (where he was dog #8) and was given to the family as a present. Only just passed a dog training course. Ripped up the first ever Radioactive Man comic, Homer's expensive 'Assassin' trainers and the Simpsons' family blanket. After running away from home, was caught by Mr Burns and trained as a killer guard dog. Found a mate (She's the Fastest) and had 25 puppies.
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Scorpio, Hank (Mr) - President of Globex Corporation and evil mastermind. Arch nemesis of the now deceased James Bont. Gets the best out of his workers, even Homer Simpson.
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Scratchy
- The cat in the cartoon "Itchy and Scratchy", shown in Krusty's show. Always loses.
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Serak (the Preparer)
- He is one of the aliens (the other two being Kodos and Kang) who frequent the Treehouse of Horror episodes. They are large, green, one-eyed, octopus-like creatures who dribble a lot. He is the spaceship's chef and prone to crying when people accuse him of cooking humans.
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Seth
- Old hippie who works at the Groovy Grove Natural Farm along with Munchie. Used to be in the same commune as Mother Simpson.
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Seven Duffs, The
- The walking Duff bottles that frequent the Duff Gardens leisure park. They include Tipsy, Surly, Sleazy, Queasy and Remorseful.
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Shapiro, Cecile
- Student in the ELCfGC class Bart briefly attends. Works on a hamster experimentation project.
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She's the Fastest
- Was briefly a pet of the Simpsons and was mate of Santa's Little Helper. Mother of 25 puppies.
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Sherman, Jay (Mr)
- New York film critic.
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Sherri
- One of Bart's classmates. Twin with Terri. Father works at SNPP.
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Shutton, Dave (Mr)
- Investicative reporter, primarily for the Springfield Shopper.
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Sideshow Bob
- See Terwilliger, Robert
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Sideshow Mel
- See van Horne, Melvin
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Sideshow Rahem
- Former sidekick of Krusty the Clown.
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Simmons, Beatrice "Bea" (Miss)
- Retiree at the Springfield Retirement Castle. Fell in love with Abe Simpson and left him all of her money when she died.
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Simmons, Mindy (Miss)
- Engineer and temptress at the SNPP. Fell in love with Homer. Looks and sounds like Michelle Pfeiffer, although with similar characteristics to Homer.
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Simpson, Abraham J (Mr) - Universely known as Grampa, he is Homer's father. Lives in the Springfield Retirement Castle with Jasper. Bart and Lisa used him as a front to their "Itchy and Scratchy" scripts. Fell in love with Bea Simmons who left him all her money when she died. Was a member of the Springfield Stonecutters. Resurrected the "Simpson & Son's Patented Revitalising Tonic" formula which his great-grandfather had invented. Was the Seargeant of the Flying Hellfish squad in the Second World War.
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Simpson, Bartholomew J - Oldest child of the Simpsons. A 4th grade tearaway and never seems too bright. Responsible for the grafitti works of El Barto. Principal Skinner's nemesis, although they have a grudging respect. Friends with Milhouse and Lewis. Has had crushes on Laura Powers and Jessica Lovejoy. Makes repeated prank phone calls to Moe's Tavern. Idolises Radioactive Man and was briefly in joint ownership of the first ever Radioactive Man comic. Auditioned to play Fallout Boy in the film version but wasn't tall enough. Stole Jebediah Springfield's statue's head. Led a rebellion at Kamp Krusty. Became the "I Didn't Do It Boy" while working at Krustylu Studios for Krusty. Repeatedly foiled Sideshow Bob's dastardly plans. Worked at Fat Tony's mobster hangout as a barman. Almost became the heir to Burns' millions. Hatched a plan to return Springfield's lemon tree after Shelbyville kids stole it. Was a member of the Mighty Pigs pee-wee hockey team.
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Simpson, Homer Jay (Mr) - The father of the Simpson household and a worker at the Springfield nuclear power plant. Loves donuts and steak. Once a member of the barbershop quartet, the "Be Sharps". Was mistaken for Bigfoot when on a camping trip. Became Mr Plow one long winter and won the key to the town, only to have it won from him by Barney Gumble. Was advertised as "Bottomless Pete: Nature's Cruelest Mistake", in Captain McCallister's restaurant window. Finally managed to become a member (908) of the Stonecutters when he found his father was one, and was then descovered to be the Chosen One. Member of the Pin Pals bowling league team. Almost had affairs with SNPP temptress Mindy Simmons and up-and-coming country music star Lurleen Lumpkin. Says a lot of stupid things (Homerisms).
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Simpson, Lisa Marie - Intelligent, saxophone playing second child of the Simpsons. In 2nd grade. Won a regional Reading Digest essay competition. Idolised the late Bleeding Gums Murphy. Always wanted a pony. Once the "Little Miss Springfield". Desired by Ralph Wiggum. Was a member of the Kwik-E-Mart Gougers pee-wee hockey team. Has crushes on several actors called Corey. Once tried to find the sweet boy inside Nelson Muntz. Produced Lisa Lionheart, a rival doll to Malibu Stacy, with the help of Stacy Lovell.
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Simpson, Maggie
- Youngest of the Simpsons' children. Always sucks a dummy. Led a rebellion at the Ayn Rand School for Tots. Hit Homer over the head after wathcing "Itchy and Scratchy" cartoons. Gave Mr Burns his bear Bobo back and at a different time, shot him accidentally after he stole her lolly.
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Simpson, Marge (nee Bouvier) - The mother of the Simpson household and married to Homer . Uses hair dye #56. Got a leading role in the musical 'Oh Streetcar'. Almost had an affair with bowling pro Jacques. Developed a gambling addiction. Went on lam with her neighbour Ruth Powers. Commissioned to paint a portrait of Mr Burns. Had a brief spell in jail for shop-lifting. Had a fear of flying before being cured by Dr Zweig.
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Simpson, Mona (Mrs) 
Married to Abe Simpson and mother of Homer. Left Grampa when Homer was small because the police were chasing her after she was part of a group who broke into Burns' germ warfare lab. Lived with hippies for most of her life with the aliases Mona Stevens, Martha Stewart, Penelope Olsen and Muddy Mae Suggins.-
Sinclair, Llewellyn (Mr)
- Flamboyant director of theatrical productions at Springfield Community Centre. Successes include "Hats off to Chanukah" and "Oh! Streetcar!" Likes amaretto.
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Skinner, Agnes (Mrs)
- Principal Skinner's mother. She won't let him do anything. Always fights with her son over inflatable bath pillows.
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Skinner, Seymour (Principal) - The principal at Springfield Elementary school. Fought in Vietnam as a Sergeant, was shot in the back by his own troops and was imprisoned as prisoner 24601 for two years in a Viet Cong internment centre. Is actually called Armin Tamzarian, but took his Vietnam sergeant's name, after the officer went missing in action, to give himself a better life. Once a member of the barbershop quartet, the "Be Sharps". Lives at home with his mother, and always fights with her over inflatable bath pillows. Was a member of the Springfield Stonecutters. Almost married Patty Bouvier and has a continuing relationship with Edna Krabappel.
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Skowie
- McBain's sidekick in a number of the films of that series. Gunned down by one of Mendoza's henchmen, just two days from retirement.
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Sleazy
- One of the Seven Duffs.
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Smiling Joe Fission
- Public relations film character for Springfield Nuclear Power Plant.
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Smithers, Waylon J. (Mr) - Mr Burns' personal assistant. Has an increasingly unambiguous sexuality. Has the world's largest collection of Malibu Stacy dolls. Placed a sponge on Mr Burns' forehead which almost killed him as he sunk under the water. Was a member of the Springfield Stonecutters.
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Snake (Turkey, Chester)
- He always robs, trashes or takes away the Kwik-e-Mart store. At most other times he is in jail. Friends with Otto the bus driver. Member of the Police bowling league team until he escaped from Wiggum.
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Snowball
- The Simpsons' original cat. Was run over by the mayor's brother.
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Snowball II
- The Simpsons' second cat, after the first was run over.
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Snyder (Judge)
- The no-nonsense judge in Springfield. Dislikes Lionel Hutz, as the lawyer once repeatedly ran over his son. Participated in "The Simpsons Family Smile-Time Variety Hour".
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Spotty teenager
- Acned teenager who turns up working anywhere for a bit of cash. Has a squeaky 'breaking' voice and red hair. Always manages to mess things up.
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Springfield Cat Burgler, The
- See Malloy
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Springfield, Jebediah Obediah Zachariah Jebediah (Mr)
- Springfield's town founder. Had an argument with companion Shelbyville Manhattan (over marrying cousins) resulting in Shelbyville and Springfield being founded separately. Was probably a murderous silver tongued pirate called Hans Sprungfeld.
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Stacy (Malibu)
- See Malibu Stacy
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Stampy
- The elephant Bart won on a radio contest. Later sold to a safari park, but reappeared to helped Krusty regain his flagging audiences.
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Stanky, Samantha (Miss)
- Girl at Springfield's Catholic School who briefly attended Springfield Elementary. Once in love with Milhouse.
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Stu (Disco)
- See Disco Stu
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Stuart
- Duck worker at the SNPP
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Sue-Sue
- Socialite at the Springfield Country Club.
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Superdude
- Deceased class hamster of the 4th grade at Springfield Elementary.
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Surly
- One of the Seven Duffs.
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Sweet, Lucius (Mr)
- Don King-esque boxing manager and promoter. Once manager Moe. and currently manages Tatum. Seen at Krusty's funeral.
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Swift, Sidney
- Student in the ELCfGC class Bart briefly attends. Speaks backwards phonetically.
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Szyslak, Moe (Mr) - Owner of Moe's Tavern, the bar frequented by Homer, and is one of Homer's best friend. Has Italian and Russian origins. Once loved Marge Simpson. Was a member of the Springfield Stonecutters. Member of the Pin Pals bowling league team. Once a pro boxer known as "Kid Gorgeous".
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